These nootropics, through a wide variety of differing mechanisms of action are able to enhance memory recall, cognition and concentration on tasks at hand, particularly in people who suffer from conditions like dementia, Alzheimer’s disease, other forms of neurodegeneration and even in instances of brain trauma. Although oxiracetam and pramiracetam benefits people with these conditions, it is very popular amongst college students, entrepreneurs, and professionals. Research has determined that the majority of nootropics are non-toxic, shown to be beneficial, and carry few if any side effects. Considering research into these drugs has been consistent since the 1960s, there are still some aspects regarding nootropics that remain a mystery to experts. Nootropics, like many drugs and supplements, may not affect every individual in an equal manner even with identical doses of the same substance. Nevertheless, the majority of research that either has been completed or is ongoing shows Racetams as being both positive and promising. Two of the better-known nootropics are Oxiracetam and Pramiracetam; understanding how they are similar and different requires a closer comparison.

oxiracetam vs pramiracetam


Most nootropics are a category of chemicals called Smart Drugs, and the bulk of nootropics are part of the chemical family of Racetams. Racetams are identified by the fact that they all possess a pyrrolidone nucleus. Most Racetams are recognized as nootropics while some are considered stimulants. Racetams, like Oxiracetam, Piracetam, Aniracetam and Pramiracetam, are cerebral homeostatic normalizers and metabolic enhancers, cause improvement in cognitive development, brain integrative agents and neuro-protectants. This makes them a valued inclusion in therapies that treat brain injuries and aspects associated with memory-diminishing conditions, such as Alzheimer’s and Dementia. Even though Oxiracetam and Pramiracetam have many similar benefits, how they achieve this has many differences yet show a potential for synergy for the pair.


Pramiracetam was patented in the late 1970s in Belgium. Pramiracetam is a lipid soluble, which means it becomes more bioavailable when in the presence or taken with some form of fatty content.
Pramiracetam, due to its high-affinity choline uptake (HACU), encourages the production and release of acetylcholine within the Hippocampus as well as other areas of the brain. This is why Pramiracetam is beneficial in boosting and maintaining memory formation and recall. Pramiracetam is considered to be quite powerful in comparison to many of the other nootropics; in fact, it can be 10 to 30 times more influential in some cases. The average recommended dose of Pramiracetam is approximately 1200 mg per day, which is broken into either 2 or 3 doses, which is considerably lower than most of the Racetam nootropics. Oxiracetam qualifies as a nootropic, but it is also regarded as a stimulant in certain circumstances. This could be due to the user’s overall experience of Oxiracetam having a more prolonged effect than other Racetams. This is due to its longer-lasting chemical half-life, which allows Oxiracetam to remain in an individual’s system longer and causes an increase in the amount of time that its benefits are felt.Buy Pramiracetam Capsules

Of course, while these nootropics do have much in common there are some distinct differences. By and large, Oxiracetam is remarked to be better for longer periods of continued administration and seems to aid most individuals by improving memory faculty and focus while learning. Pramiracetam, on the other hand, seems to be most beneficial in areas of recall and maintaining of memory. While both nootropics are incredibly useful, they work in different ways. Both Oxiracetam and Pramiracetam, like the rest of the Racetam chemical family, have little to no side effects. This makes either Pramiracetam or Oxiracetam great choices when considering taking or using nootropics.

Overall, Pramiracetam is the stronger of the two, and its effects are more noticeable and with a rapid onset, at least in the reports of increased “brain activity” and “memory-boosting” the experts call it. Interestingly, Pramiracetam has been shown in a study to have benefits remaining even after use has been halted, so don’t count Pramiracetam out all the way in the long-term. In a separate study, Oxiracetam was shown to improve infant mice’s learning rate simply if Oxiracetam had been administered to the mother during pregnancy. While similar yet very different to each other in rather unique aspects, the discussion regarding their comparison doesn’t seem to be coming to an end any time soon within numerous nootropic communities.


While usage of Oxiracetam or Pramiracetam has not been remarked to result in unwanted effects for most customers, there is still a possibility an individual may experience adverse side effects. These side effects are often described only as a mild or temporary feeling of uncomfort. Pramiracetam can potentially lead to headaches and insomnia. Oxiracetam has some of the lower number of side effects, even those like insomnia and headaches are unlikely. These headaches are easily associated with much of the Racetam chemical family due to their shared nature of stimulating the Acetylcholine neuro-receptors, this side effect is easily combated with the increased supplementation of choline. That said, it is beneficial to speak to a professional or your own doctor before taking any drug on a regular basis, whether for medicinal or supplemental use. While Pramiracetam and Oxiracetam are safe and pose minimal threat to most user’s health, it is still recommended to get proper advice and to practice personal due diligence in researching any nootropic.

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First these nootropics are most beneficial as treatments for conditions like Alzheimer’s and amnesia, as well as, other side effects of traumatic brain injuries. The idea of a nootropic pill that encourages greater mental dexterity, creates a more focused mind, and can contribute to improved intellect is enticing to any person. High school overachievers, stressed-out college students, and even professionals pressured by deadlines may be attracted to nootropics like Oxiracetam and Pramiracetam, and their label as Smart Drugs. As mentioned often, one should always practice personal due diligence when considering taking any nootropic. A majority of studies show that there are no serious ramifications or side effects from taking these nootropics. Furthermore, these studies focused on the use of appropriate dosages and show that abuse of the substance could potentially lead to unwanted discomfort. Luckily though, most of the side effects have straightforward remedies, which most often can be as simple as including a few more eggs in one’s diet to adjusting the amount taken. The research into these nootropics is increasing hope for those whose loved ones suffer or individuals who suffer with dementia, Alzheimer’s, a traumatic brain injury, emotional disorders, and other forms of neuro-degeneration. Additionally, these studies are also splendid proof that nootropics are just as beneficial for those healthy in mind as those who are not. That, in and of itself, makes further research on nootropics not only benevolent in nature and worthwhile in a cause, but needed for humanity.



Smart Drugs for Thought (2015). Oxiracetam vs Pramiracetam: Dosage, Side Effects and Benefits

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