Uridine: What is Uridine?

Uridine can be found in many foods such as tomatoes, beer, and breast milk. Uridine can bypass the blood brain barrier effectively by one of two neuro transporters known as equilibrative and concentrative. Uridine also when administered orally causes a production of CDP-choline.

Uridine is a Ribonucleoside, which are the building blocks for both RNA and DNA. Uridine is one of the four essential components of RNA (ribonucleic acid), and is absorbed within the intestinal tract. Studies have shown that supplementation of Uridine along with Choline and fish oil increases synaptic formation and function, showing improvement in persons suffering from mild Alzheimer’s Disease. This nootropic may increase or raise dopmaine levels within the brain.

This nootropic is synergistic with fish oil (DHA) and many choline sources. Stacking this nootropic with choline sources or fish oil supplements may enhance and increase cognition to higher levels within the brain. The choline sources commonly used with this Uridine are CDP Choline or Alpha GPC. Uridine has been shown to have anti-depressant properties and may increase some level of dopamine within the brain.

Open-Label Uridine for Treatment of Depressed Adolescents with Bipolar Disorder Douglas G. Kondo, M.D., Young-Hoon Sung, M.D., […], and Perry F. Renshaw, M.D., Ph.D., M.B.A.

In one study with a control group, Uridine was shown with other supplements to help improve the overall spacial memory of rats in a variety of tests done. Including hippocampus-dependent learning and an improvement of search strategy. J Alzheimers Dis. 2013 Jan 1;37(1):233-45. doi: 10.3233/JAD-130179. Improved spatial learning strategy and memory in aged Alzheimer AβPPswe/PS1dE9 mice on a multi-nutrient diet.

Uridine Dosage

The recommended dosage of Uridine is usually 500-1000 mg per day, taken as 250 mg individual dosages, two in the morning one in the afternoon and a final dose in the evening. This nootropic supplement is sold in capsule, tablet and powder form.

Does Uridine Work?

Uridine has several potential mechanisms of action from the increase of CDP-choline through its breakdown, increasing synaptic health and function, and also having cardioprotective qualities. This nootropic helps promote overall brain health and functionality while also helping with overall health through its cardioprotective effects.

There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Uridine would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.


Neuro Stasis® – Uridine