Uridine: What is Uridine?
Uridine: What is Uridine?
Uridine Monophosphate, also known as UMP, is one of four major components of ribonucleic acid (RNA); the other three are adenosine, guanine and cytidine. Below are products containing uridine in the form of RNA. However, uridine in this form is bioavailable. It is destroyed by the liver and gastrointestinal tract, and the food intake does not increase the level of uridine in the blood. In infant’s consuming breast milk or commercial infant formula, uridine monophosphate present as, and this is indeed a source of uridine bioavailability and enters the blood. Consumption of food rich RNA may lead to increased levels of purines (adenosine and guanosine) in the blood. High levels cause an increase in purines uric acid levels and can impair or lead to the development of diseases such as gout. Moderate consumption of yeast, about 5 grams per day will provide adequate levels of uridine, for health improvement with minimal side effects. It has been suggested that RNA from yeast products must be chemically reduced, if these products are consumed in large amounts (50 g or more per day) as a source of protein. However, such processing is expensive and is rarely used. Harvard researchers have reported that the addition of uridine and EPA / DHA omega-3 fatty acids in rats act as antidepressants. Uridine plays an important role in glycolysis pathway galactose. There is no catabolic process for the metabolism of galactose. Thus, the galactose into glucose and glucose metabolized in the general way. After converting incoming galactose-1-phosphate (Gal-1-P), it participates in the reaction with UDP-glucose, a glucose molecule attached to a molecule of UDP (uridine di-phosphate). This process is catalyzed by the enzyme galactose-1-phosphate uridiltransferazy and transmits the UDP galactose molecule. The result is a molecule UDP-galactose and glucose molecule-1-phosphate. This process continues for the galactose molecule glycolysis.
Often uridine is used in conjunction with cytidine. Nucleotide such as uridine triphosphate and cytidine monophosphate is used to treat diseases of the central nervous system. Cytidine active substance participates in the synthesis of complex lipids forming the neuronal membrane, preferably sphingomyelin – a chief component of myelin membrane. Furthermore, cytidine is a precursor of nucleic acids (RNA and DNA), is a serious component of cell metabolism. Uridine active substance acts as a coenzyme participating in the synthesis of neuronal structures of glycolipids and myelin sheath, thereby complementing the action of cytidine. Uridine is a source of energy in the process of muscle contraction. The combined effects of cytidine and uridine contribute to the regeneration of the myelin sheath, as well as the proper conduction of nerve impulses and restore muscle trophism.
Indicated for the treatment:
– Neuropathies osteoarticular etiology (lumbago, sciatica);
– Neuropathies metabolic etiology (diabetic, alcoholic polyneuropathy);
– Neuropathies infectious etiology (shingles);
– Inflammation of the facial nerve;
– Inflammation of the trigeminal nerve;
– Intercostal neuralgia;
Perform classical pharmacokinetic studies practically impracticable, because the medicament contains physiological products and cannot determine with accuracy the amount of endogenous and exogenous components. Due to the heavy load radiological also impossible to carry out analysis using labeled (radioactively) product. Given the low toxicity of the drug, overdose is unlikely even if unintentional excess of therapeutic doses. It does not affect driving and work that requires high concentration and speed of psychomotor reactions. In patients with hypersensitivity may develop allergic reactions.
Uridine additional information
Uridine can be found in many foods such as tomatoes, beer, and breast milk. Uridine can bypass the blood-brain barrier effectively by one of two neuro transporters known as equilibrate and concentrative. Uridine also when administered orally causes a production of CDP-choline.
Uridine is a Ribonucleoside, which are the building blocks for both RNA and DNA. Uridine is one of the four essential components of RNA (ribonucleic acid), and is absorbed within the intestinal tract. Studies have shown that supplementation of Uridine along with Choline and fish oil increases synaptic formation and function, showing improvement in persons suffering from mild Alzheimer’s Disease. This nootropic may increase or raise dopamine levels within the brain.
Stacking Uridine with an Omega or a Nootropic
This nootropic is synergistic with fish oil, krill oil and many choline sources. Stacking this nootropic with choline sources or omega-3 supplements may enhance and increase cognition to higher levels within the brain. The choline sources commonly used with Uridine are CDP Choline or Alpha GPC. Uridine has been shown to have anti-depressant properties and may increase some level of dopamine within the brain. Uridine has been often paired or stacked with omega-3 and n-3 fats in order to amplify the anti-depressant and mood enhancement effects. It’s been said that Krill Oil is a much better omega-3 source to use with this nootropic, as it consist of astaxanthin and omega-3 phospholipids (EPA and DHA are much more absorbable with this fatty acid structure).
Open-Label Uridine for Treatment of Depressed Adolescents with Bipolar Disorder Douglas G. Kondo, M.D., Young-Hoon Sung, M.D., […], and Perry F. Renshaw, M.D., Ph.D., M.B.A.
In one study with a control group, Uridine was shown with other supplements to help improve the overall spatial memory of rats in a variety of tests done. Including hippocampus-dependent learning and an improvement of search strategy. J Alzheimer’s Dis. 2013 Jan 1; 37(1): 233-45 doi: 10.3233/JAD-130179. Improved spatial learning strategy and memory in aged Alzheimer AÎ²PPswe/PS1dE9 mice on a multi-nutrient diet.
Uridine (UMP) Dosage and Usage
The recommended dosage of Uridine is usually 500-1000 mg per day, taken as 250 mg individual dosages, two in the morning one in the afternoon and a final dose in the evening. This nootropic supplement is sold in capsule, tablet and powder form. Within the nootropic community (longecity), statements regarding very high Uridine Monophosphate dosages have been noted. There have been instances where psychonauts have experimented with up to 2 gram dosages and felt positive uplifting and mood elevating effects. There hasn’t been any serious or minimal side effects reported over the years of trials. Although CDP-Choline metabolizes into very small or micro amounts of Uridine, there isn’t enough to gain the beneficial effects of Uridine Monophosphate. There are small contents of Uridine contained in spirulina, but it would never suffice to the effects of even the smallest dosages.
Does Uridine Work?
Uridine has several potential mechanisms of action from the increase of CDP-choline through its breakdown, improving synaptic health and function, and having cardioprotective qualities. This nootropic helps promote overall brain health and functionality while also helping with comprehensive health through its cardio-protective effects.
There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Uridine would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.