Sunifiram: What is Sunifiram?

Sunifiram, DM-235, is derived from Piracetam but is not considered a Racetam class chemical due to the chemical structure of Sunifiram. Sunifiram is a ampakine that gains some effectiveness through the increase of the glycine receptor binding in regards to NDMA.

Sunifiram is a piperazine alkaloid that shares a chemical shape of both Unifiram and Sapunifiram. Sunifiram has been shown in a study that after taking it for 7 to 12 days, an increase in potentiation of NDMA receptors is seen. Afterwords Sunifiram begins to show positive improvement in AMPA receptors as well as acetylcholine (ACh) receptors. It shares a structure based off of Piracetam, however the major difference is that Sunifiram’s pyrrolidine backbone is left open after attaching a piperazine structure to it.

Sunifiram along with Unifiram were shown in a study to help improve the output of acetylcholine to the prefrontal cortex in lab rats, while also having an anti-amnesiac effect, this study suggests that it may be due to DM-235′s effects on the AMPA receptors that cause this. Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers (CNS Drug Rev. 2006 Spring;12(1):39-52).

In one study Sunifiram was found to help increase the long term potentiation in olfactory bulbectomized mice. Sunifiram was also found to improve short term memory assessment, however Sunifiram did not show any signs of any anti-depression effects. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice (Behav Brain Res. 2013 Apr 1;242:150-7. doi: 10.1016/j.bbr.2012.12.054. Epub 2013 Jan 4).

Sunifiram Dosage

The recommended dose of Sunifiram is 7mg and it may be taken up to three times within a day. This cognitive enhancer is sold in capsules, powder, and tablet form.Sunifiram

Does Sunifiram Work?

Sunifiram shows positive improvements in regards to long term memory and acetylcholine usage. This nootropic source targets and stimulates the AMPA and NDMA glutamatergic receptors. This makes DM-235 a keen choice in regards to a stand alone nootropic.

There are still many variables that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective this smart drug would be for a specific person. It all comes down to their own needs, current cognitive ability and lifestyle choices.


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