Piracetam – What is Piracetam?
Piracetam – What is Piracetam?
Piracetam was developed in 1960s in Belgium as a ‘smart drug’. It is a recurring plagiaristic form of GABA, also known as aminobutyric acid. Since its discovery and usefulness detection, piracetam has been used as a nootropic agent for the enhancement of memory in human beings. Piracetam is an exceptional nootropic with low contagiousness and insalubility levels and incurs a small number of side effects. Its effectiveness in the treatment of ischemia, cognitive impairment, stroke, and dementia is acknowledged widely. It also contributes to the cognition enhancement of dyslexic and dyspraxic children. Moreover, its usefulness is equally apparent in Down Syndrome patients whereby piracetam is employed to slow down the rapid aging of the brain. It also contributes as a modulator of brain metabolism, neuro-protection and neuro-plasticity. Piracetam is also known to have anti-seizure or antiepileptic effects. Furthermore, it is also used for the reduction of symptoms associated with anxiety, withdrawal from alcohol, and clinical depression (Grossman, Stewart, Gaikwad, Utterback, Wu, Dileo, Frank, Hart, Howard & Kalueff, 2011).
How does Piracetam work?
The action mechanisms of piracetam are still vaguely understandable even though various clinical and experimental studies have been conducted. Nevertheless, this remarkable smart drug is used for the modulation of membrane fluidity. As a consequence, it demonstrates certain effects on the release of neurotransmitters and receptor binding. It also results in improved cell functioning and better viscosity of cell membranes. In addition, piracetam “appears to reduce erythrocyte adhesion to vascular endothelium, hinder vasospasm, and facilitate microcirculation” (Winblad, 2005) at a vascular level. Moreover, it is also known to have an involvement in the activation of acetylcholine, which helps the brain to take up oxygen with improved blood flow. Piracetam is also considered a great promoter of information transference from one brain hemisphere to the other. It enhances motor planning by creating a coordination between both hemispheres.
Short and Long term Effects & Side Effects
Piracetam has certain short-term effects as suggested by the current evidence. This is an effective supplement for the supplication of temporary gains in memorization, learning capacities, and intelligence boost. However, there is still no proof, whether such short-term effects could be sustained in the future or not. As far as the long-term effects of piracetam are concerned, it has numerous advantages for the patient. First, it helps in the reduction of symptoms associated with the age-related decline in an individual’s cognitive skills. By reducing brain aging signs, piracetam helps in the improvement of overall cognition longevity (Scheuer, Rostock, Bartsch & Müller, 1999). On the other hand, there are certain side effects associated with the long term usage of piracetam. These side effects include weight increase, hyperkinesia, sleepiness, shakiness, headaches, and nervousness (Stokes, 2004). It is, however, important to remember that piracetam is one of the safest smart drugs with no severe side effects.
Additional Information on Piracetam
Piracetam is a cognitive enhancer and memory enhancing supplement. Many people across the world use the nootropic, piracetam, to effectively retain knowledge and improve memory. Piracetam is utilized by both younger and older healthy individuals. From recent and past clinical studies and research, Piracetam has been determined to support memory and aid individuals experiencing memory loss and difficulties in the ability to retain knowledge. Piracetam may enhance, elevate, and improve cognitive functions and abilities linked and associated to the central nervous system, memory development and memory processes. Piracetam may benefit with senile dementia, dyslexia, alcoholism & withdrawal syndrome, acute ischemic stroke, circulatory disorders, heart disease, Raynaud’s, alzheimer’s disease, cortical myoclonus, obsessive-compulsive disorders (OCD), and traumatic brain injury (TBI). Piracetam is a nootropic nutraceutical that may improve and enhance memory and other intellectual functions. Piracetam is commonly prescribed for cognitive impairment and dementia in several countries of continental Europe. In a thorough clinical study and examination done by N. N. Zavadenko and L. S. Guzilova, piracetam was found to have positive therapeutic effects on impairments to the higher mental (memory, attention, executive) and motor (coordination) functions and on measures of the speeds of cognitive and motor operations. The nootropic substance, piracetam, has been studied in countless widespread clinical experiments. Piracetam has demonstrated inarguable results in the treatment of post-stroke aphasia, epilepsy, cognitive decline following heart and brain surgery, dementia, and myoclonus. Piracetam’s vascular effect has designated its use for patients suffering from vertigo, dyslexia, and sickle-cell anemia.
Piracetam and the Corpus Callosum
Neuro-Boost® Piracetam may certainly increase the communication between the two hemispheres of the brain, and increases activity of the corpus callosum. Right and Left brain have different and complementary functions between each other. The left-brain function associated with academic or analytical intelligence that consists of ability speaking, the ability to process grammar, reading and writing, memory (name, time and events), logic, numbers, analysis, and others. While the right brain is the place for the development of the things that are artistic, creativity, feelings, emotions, style, music, imagination, fantasy, color, recognition of self and others, socialization, personality development. Experts say the left brain is a controller of IQ (Intelligence Quotient), while the right brain plays an important role for the development of EQ (Emotional Quotient) a person. Piracetam allows both hemispheres to interact and transmit with one another more adequately.
What is the chemical background of Piracetam?
The chemical name for Piracetam is 2-oxo-1-pyrrolidine acetamide; it shares the same 2-oxo-pyrrolidone base structure with 2-oxo-pyrrolidine carboxylic acid (pyroglutamate). Pyrrolidine is a common element that is often found in most racetam compounds.
Piracetam Dosage and Suggested Usage
Although not applicable to every individual, the standard dosage of piracetam is 1600 mg thrice a day in the starting. This dose may vary if the patient is a child. The recommended piracetam dosage varies based on the reason of use, usually ranging from 1.6–9.6 grams daily (2–12 pills daily). Some people report better results when taking 1–2 pills per hour for 4–6 hours or taking 4–8 pills at once for the first few days to notice an effect. Even when given in high doses over a long period of time, piracetam has never been medically recorded or documented to have any negative or adverse side effects. Very few cases of headaches and insomnia have been discussed from a few personal experiences due to a lack of natural choline levels. Experienced users have made suggestions to supplement Piracetam with Choline. Choline can boost the effects of Piracetam and will eliminate any possible side effects that this smart drug may cause. Choline supplements can be purchased from a local vitamin store or nootropic vendor. Choline is often found in B-Complex and is naturally abundant in eggs, beef liver, and cauliflower. Alpha GPC, CDP Choline, and citicoline are the highest and most expensive grades of choline, but choline bitartrate will work just fine.
Using Piracetam in a Nootropic Stack
Piracetam, one of the most well-known racetams, has been used with many other supplements or nootropics. Over the past couple years or decades, piracetam has been supplemented with choline sources, other racetams, prescription drugs, and common cognitive enhancers. The piracetam and choline stack, one of the more typical and widely used blends, has proven to be very effective in leveraging specific neurotransmitter and receptor actions. Despite the fact that all racetams have different half-lives and distinct effects, they all work as a team when taken or stacked together. Piracetam combined with Aniracetam enhances AMPA receptor functions, while Piracetam stacked with Fasoracetam may enhance anxiolytic or anti-depressive effects. On another note, this racetam has been used in conjunction with supplements and vitamins found at your local vitamin shops. B-Complex, potassium, huperzine-A, vinpocetine, caffeine are only some of the supplements that are paired with this nootropic. The effectiveness of piracetam has been shown to increase with the use of some of these supplements. Potassium, calcium and b-complex are some of the more typical sources used to improve the performance of piracetam. There are endless combinations that you can add to your daily piracetam regimen. In general, piracetam is safe to stack with various supplements, vitamins, and the entire racetam class of nootropics.
Does Piracetam Work?
Piracetam may boost the overall functions of the (ACh) neurotransmitters and receptors. Acetylcholine, abbreviated as (ACh), is implicated in memory processes and development. Choline sources, like Alpha GPC and choline bitartrate, increase the production of Acetylcholine. Specific racetams and nootropics may enhance or stimulate ACh receptor activities. Not only is ACh implicated in memory processes, the chemical compound is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms, including humans.
If you would like to know more about Piracetam, please don’t hesitate to stop by our Piracetam Research Page. We have conducted our extensive studies to find medical documents, clinical results and trials on piracetam.