Idebenone: What is Idebenone?
Idebenone: What is Idebenone?
Idebenone is a drug designed to treat Alzheimer’s disease, there are conflicting reports about the possible efficacy of idebenone in Alzheimer’s disease, and Huntington’s disease. The European Medicines Agency has found that in Friedreich’s ataxia potential benefit of treatment outweigh the risk of them so permitted application was not given. Idebenone has a structural similarity to the coenzyme Q, and Idebenone improves blood circulation and oxygen delivery to brain-tissue. Idebenone also stimulates metabolic processes in the brain: activating the synthesis of glucose, ATP, and promotes elimination of lactate. Lipid peroxidation slows and prevents neuronal membranes and mitochondria from damage. Idebenone modulates neurophysiological responses of brain structures. The efficiency in the complex therapy of inherited mitochondrial diseases (MELAS-syndrome, Leber’s optic atrophy, a disease Leia) and Friedreich’s ataxia.
Short term and long term effects
Generalizing the data presented above, it can be noted that idebenone is effective in cognition in patients with dementia in the elderly and patients with fewer severe disabilities in mnestic sphere. With a wide spectrum of action (antioxidant, nootropic, neuro protective, as a psychostimulant), this drug improves memory in patients with dementia of various etiologies. Moreover, its effects are related as auditory-verbal and visual-spatial short-term and delayed memory, and speech, including written, individual types of gnosis, thinking and attention. In some cases, there is an improvement in the mood. Changes in neurological status expressed accelerated motion, minor reduction of the parkinsonian syndrome. Nobenom therapy was well tolerated; treatment discontinuation due to the occurrence of side effects was not required in any case. This allows us to recommend noben for the treatment of cognitive disorders in the various neurological diseases in a wide age range.
How does Idebenone work?
Idebenone is a synthetic analogue of coenzyme Q10. Coenzyme Q10 (ubiquinone) –vitamin-like compound that is produced in the liver subject to receipt in the required amount of vitamins B2, B3, B6, C, folic and pantothenic acid. In case of a shortage of any of these vitamin’s synthesis of coenzyme Q10 suppressed. Ubiquinone stimulates the production of the primary energy molecules – adenosine triphosphate (ATP). With age, the content of coenzyme in the body falls, and is useful for slowing the aging process and prevents degenerative diseases. The use of natural coenzyme Q10 has several limitations. Ubiquinone molecule is quite big (about 50 carbon residues in the side chains), and having a high hydrophobicity impedes its passage through the membrane. In addition, under certain conditions instead of the antioxidant effect may occur pro oxidant properties soedineniya.S in order to overcome these shortcomings, attempts to synthesize derivatives of coenzyme Q10, retains all its positive properties of natural counterpart, but devoid of its drawbacks. To date, only one of the plurality of synthesized molecules in this series has been approved as a drug. Idebenone inhibits lipid peroxidation by protecting neuronal membranes and mitochondria from damage. Coenzyme Q10 is a component of the electron transport chain, located in the inner mitochondrial membrane. It accepts electrons from complexes, I (NADH-ubiquinone reductase-oksidore) and II (succinate dehydrogenase) for onward transmission to complex III (ubiquinone reductase tsitohroms). Oxidative phosphorylation, is realized by the production of ATP, is an important process used in the production of energy to maintain the functions of organs such as the brain, heart, myshtsy.Naryadu with metabolic and trophic effect of idebenone has both nootropic properties. Increasing the metabolous processes in the brain by activating the synthesis of glucose, ATP, improves blood circulation and nutrition of tissues, it also contributes to elimination (removal) of lactate. In clinical practice, idebenone improves the speed of sensorimotor reactions, has a marked effect on specific cognitive processes, improving performance and short-term memory and attention. Additionally, the compound possesses a strong antioxidant effect. Thus, the indications for the drug are: tse-rebrovaskulyarnye disorders, asthenic conditions, psycho-organic syndrome, emotionally labile disorder. From the first days of idebenone shows antiastenicheskoe, psychostimulant and antidepressant effects; nootropic effect manifests in 3-4 weeks. General cytoprotective efficacy of the drug determines its use in gerontology.
Idebenone has a metabolic and trophic effect. Increases the metabolic processes in the brain by activating the synthesis of glucose and ATP, improves blood circulation and oxygenation of brain tissue, promotes the excretion of lactate; increases the intensity and speed of neurophysiological responses of brain structures. Slowing lipid peroxidation, prevents neuronal membranes and mitochondria from damage. From the first days of use, it exhibits antiastenicheskoe, psychostimulant and antidepressant effects; nootropic effect manifests itself after 3-4 weeks of reception.
Additional Information on Idebenone
Idebenone was first developed and made in Japan by the Takeda Pharmaceutical Company to aid in treating cognitive degenerative diseases and defects such as Alzheimer’s. Eventually the Swiss company Santhera Pharmaceuticals began testing it as a treatment for neuromuscular diseases. This nootropic has many similarities that have caused it to be compared to CoQ10 by commercial businesses.
Idebenone has been shown to have anti-aging and antioxidant properties. This nootropic may promote the brain health longevity and stimulate nerve growth in most individuals. Over the years, this substance has been labeled to be a cognitive enhancing nootropic and/or an antioxidant.
Idebenone is a soluble in alcohol, and methanol. However, is insoluble in water. Idebenone has been shown to have some neuro protectant and regenerative qualities such as the prevention of platelet aggregation and the rejuvenation of cholinergic and monoaminergic changes to murine models. This nootropic has also been shown in other studies to display a capability of increasing nerve growth factor production in astrocytes.
A study found Idebenone prescriptions in Argentina had grown significantly in a year. Idebenone is being used as a pharmaceutical to aid in the treatment of cognitive impairment and dementia treatment in young to middle-aged patients in Argentina. Brain Inj. Medicina (B Aires). 2013; 73(3): 213-23 [Drugs used for cognitive impairment. Analysis of 1.5 million prescriptions in Argentina]
Idebenone not only helps improve the cognitive functionality but when used with either Melatonin or arginine it has been found to help preserve liver functionality. Showing that Idebenone has a wide array of beneficial qualities to it beyond being a nootropic. World J Gastroenterol. 2012 Nov 28; 18(44): 6379-86 doi: 10.3748/wjg.v18.i44.6379.
Dietary supplementation of some antioxidants against hypoxia.
The suggested dosage of Idebenone is usually 125-375 mg per day, taken as 125 mg individual dosages, one in the morning and one in the afternoon. Idebenone is sold in capsule, tablet and powder form.
Does Idebenone Work?
Idebenone has several potential benefits from improving visual conditions, regenerating some of the neural pathways such as the cholinergic, and also has positive benefits in overall health. This makes Idebenone a health-conscious addition to any nootropic stack. In other words, this nootropic may be added or stacked with other nootropics to benefit overall mind health and cognition.
There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Idebenone would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.