Centrophenoxine: Usage, Dosage and Effects

Centrophenoxine: What is it?

Centrophenoxine: What is Centrophenoxine?

Centrophenoxine, also known as Lucidril, Meclofenoxate or meclofenoxateor, combines PCPA (paracholrphenoxyacetic) and DMAE (dimethylaminoethanol) (Antiaging-systems.com, 2014). Recognized as one of the original drugs to combat aging, Centrophenoxine was found from early animal studies to reduce lipofuscin levels. Europeans use the drug to promote brain energy, or neuro energizing, with glucose uptake (Eternity-medicine.com, 2014). It is cholinergic, promoting absorption of DMAE.


Centrophenoxine is an over-the-counter oral supplement recommended for prevention and treatment of senile dementia, notably Alzheimer’s disease; it can be productive for correction of cognitive decline and loss of memory (Marcer and Hopkins, 1977). There are indications Centrophenoxine is efficient for ADHD (Nootropics, 2014).

Method of Action

Lipofuscin levels, essentially accumulated potassium, are reduced. Studies have shown a correlation between low lipofuscin levels and optimum cellular function (Antiaging-systems.com, 2014). The primary fuel used by the brain is neuronal glucose, which is increased by Centrophenoxine. In addition to increasing the uptake of oxygen and production of carbon dioxide, the drug promotes RNA, protein, and other essential chemicals in the brain. DNA in the nucleus of the cell provides RNA, which allows neurons to properly encode memory and repair damage to brain cells.

Centrophenoxine Dosage and Suggested Usage

Recommended dosage for young, healthy adults is one or two 250 mg tablets every day. Elderly adults in the process of mental deterioration may require three to six 250 mg tablets day after day. It is recommended that intakes coincide with breakfast and lunch to prevent problems with sleeping.

Centrophenoxine Possible Side Effects

Acetylcholine excess may result in muscle tension in the neck, jaw, or shoulders. Side effects may be prevented by taking breaks occasionally of once weekly. If dizziness, hyperexcitability, headache, restlessness, issues with the gastrointestinal tract, problems with sleeping, nausea, or irritability occur, cessation of Centrophenoxine for a few days should stop side effects. Treatment can continue with a smaller dosage. Due to Centrophenoxine being a subset of DMAE, teratogenic effects may be exerted, resulting in birth defects. Women the age of child-bearing and mother’s breast-feeding should abstain from ingestion (Examine.com, 2014). Centrophenoxine is also contraindicated individuals suffering from Parkinson’s, seizure disorders, or major depression.

Centrophenoxine Studies

Dr. Raymond Bartus conducted research showing piracetam enhances memory and learning significantly more when combined with acetyl-L-carnitine and a cholinergic compound like meclofenoxate. Human studies find Centrophenoxine restores well-being intellectually. Experimental studies show the drug is effective in reducing deposit of lipofuscin in nerve cells in the brain, improving the mental capacity in individuals with senile dementia and in health adults, also (Fulop et al, 1990). Many scientific experiments have shown a decrease of RNA with an increase in age is reversed; RNA increases the turnover of protein and assists in anti-aging (Eternity-medicine.com, 2010).

Addiotional Information on Centrophenoxine

Centrophenoxine is an ester of DMAE and pCPA, and is used for its neuro-protective properties as well as its abilities to enhance memory formation. It’s by the reduction of lipofuscin, a build-up of Potassium that causes brain cells to be less efficient and die, that Centrophenoxine gains its neuro-protective qualities.

Centrophenoxine is a cholinergic compound that contains DMAE, and is water soluble. Centrophenoxine increases the uptake of oxygen and glucose uptake in the brain. Through the increase of glucose uptake, Centrophenoxine helps in rectifying the damage done to the brain from aging. The brain uses 20 percent of the body’s oxygen, if the oxygen levels become deficient, the brain loses efficiency. By improving the flow of oxygen to the brain Centrophenoxine helps increase the productiveness of the brain all around.

Centrophenoxine does not just help improve the memory, but also aids in protecting memory and reversing the effects of aging on the brain. Centrophenoxine increases RNA which is used by neurons to create protein, which is used to encode memory and mend damaged cells in the brain.

One study showed that Centrophenoxine showed an increase in acetylcholinesterase activity in the brain stem in aged rats. It was concluded through this study, that the increase of acetylcholinesterase activity could be implicated in the reversal of neuro-degradation due to aging effects. Indian J Exp Biol. 1995 May;33(5): 365-8 Centrophenoxine stimulates acetylcholinesterase activity in the hippocampus of aged rats.

In a double-blind study showed that Centrophenoxine improved the cognitive performance of patients suffering from senile dementia. It was also shown to significantly reduce the deterioration index in the subjects of the test. The study was conducted over a 3-month period, and the 63 subjects were given either Centrophenoxine, and Antagonic-Stress. Arch Gerontol Geriatr. 1994; 19 Suppl 1:197-206. Antagonic-stress superiority versus meclofenoxate in gerontopsychiatry (Alzheimer type dementia).

Centrophenoxine was shown to be a conceivable treatment in patients suffering from medium-level dementia in a double-blind study conducted in 1989 on 50 residents in an old-age home. The study was over a 3-month period, and showed that 48% of the subjects experienced an improvement in cognition when taking Centrophenoxine versus the placebo which only yielded 28% of the group demonstrating improvement. Arch Gerontol Geriatr. 1989 Jul; 9(1): 17-30 Gerontopsychological studies using NAI (‘Nürnberger Alters-Inventar’) on patients with organic psycho syndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial.

Does Centrophenoxine Work?

Due to Centrophenoxine’s abilities to help in the regeneration and repairing of brain cells, it is considered a vibrantly important drug in treatments concerning Senile Dementia and Alzheimer’s Disease. There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Centrophenoxine would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.

Centrophenoxine Dosage Benefits Effects

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